Abstract

In the field of regenerative medicine，the interaction between biomaterials and cells is one of the important research topic.The physicochemical properties of the material will directly affect the cell behavior and then tissue regeneration.Among these，two of the most typical mediating methods are：1）by controlling the surface topography of biomaterials，and 2）by controlling related active ion release of the biomaterials.In the field of tissue repair and regeneration，the unique morphology effect of micro-nano topological structure can regulate cell adhesion，morphology，and alignment，and further influence stem cell differentiation and related tissue regeneration.Similarly，the active ions released from biomaterial also can effectively regulate the differentiation fate of cells，affect the phenotypes of tissue-specific cells and stem cells，and then affect tissue regeneration.However，it remains unknown how the topography or active ions released from biomaterials interacts with cells.In recent years，thanks to the rapid development of micro-nano technology and tissue engineering technology，more and more researchers are starting to study the regulation of biomaterial on cell behavior and tissue regeneration.In this chapter we are reviewing the relevant research progress from the two different perspectives of the surface micro-and nano-topology of biomaterials and bioactive ions released from materials，and focuses on the analysis of the different roles of micro and nano-topological structure signals and chemical signals in regulating cell behavior and affecting tissue regeneration.The different biological mechanisms have also been discussed.The purpose is to provide theoretical basis and application guidance for the design of tissue engineering scaffold materials and induction of functional tissue regeneration.