参考文献

[1] 向仲怀.蚕丝生物学[M].北京：中国林业出版社，2005：1-5.

[2] 丁斐，刘伟，顾晓松.再生医学[M].北京：人民卫生出版社，2012：55-57.

[3] WANG Z，ZHANG Y，ZHANG J，et al.Exploring natural silk protein sericin for regenerative medicine：an injectable，photoluminescent，cell-adhesive 3D hydrogel[J].Sci Rep，2014，4：7064-7074.

[4] TERAMOTO H，NAKAJIMA K，TAKABAYASHI C.Preparation of elastic silk sericin hydrogel[J].Biosci Biotechnol Biochem，2005，69（4）：845-847.

[5] MANDAL BB，KUNDU SC.Self-assembled silk sericin/poloxamer nanoparticles as nanocarriers of hydrophobic and hydrophilic drugs for targeted delivery[J].Nanotechnology，2009，20（35）：355101-355114.

[6] ZHANG Y，LIU J，HUANG L，et al.Design and performance of a sericin-alginate interpenetrating network hydrogel for cell and drug delivery[J].Sci Rep，2015，5：12374-12386.

[7] LIU J，QI C，TAO K，et al.Sericin/dextran injectable hydrogel as an optically trackable drug delivery system for malignant melanoma treatment[J].ACS Appl Mater Interfaces，2016，8（10）：6411-6422.

[8] JIAO Z，SONG Y，JIN Y，et al.In vivo characterizations of the immune properties of sericin：An ancient material with emerging value in biomedical applications[J].Macromol Biosci，2017，17（12）：1700229-1700234.

[9] AGRAWAL CM，RAY RB.Biodegradable polymeric scaffolds for musculoskeletal tissue engineering[J].J Biomed Mater Res，2001，55（2）：141-150.

[10] ARAMWIT P，KANOKPANONT S，NAKPHENG T，et al.The effect of sericin from various extraction methods on cell viability and collagen production[J].Int J Mol Sci，2010，11（5）：2200-2211.

[11] MOZAFFARIAN D，BENJAMIN E J，GO A S，et al.Heart disease and stroke statistics-2015 update：A report from the American Heart Association[J].Circulation，2015，131（4）：e29-e322.

[12] ALBERS G W，BATES V E，CLARK W M，et al.Intravenous tissue-type plasminogen activator for treatment of acute stroke：the Standard Treatment with Alteplase to Reverse Stroke （STARS）study[J].Jama，2000，283（9）：1145-1150.

[13] DELCROIX G J，SCHILLER P C，BENOIT J P，et al.Adult cell therapy for brain neuronal damages and the role of tissue engineering[J].Biomaterials， 2010， 31（8）：2105-2120.

[14] EGEBLAD M，RASCH M G，WEAVER V M.Dynamic interplay between the collagen scaffold and tumor evolution[J].Current opinion in cell biology，Curr Opin Cell Biol，2010，22（5）：697-706.

[15] MENEI P，MONTERO-MENEI C，VENIER M C，et al.Drug delivery into the brain using poly（lactide-co-glycolide） microspheres[J].Expert Opin Drug Del，2005，2（2）：363-76.

[16] BIBLE E，CHAU D Y，ALEXANDER M R，et al.The support of neural stem cells transplanted into stroke-induced brain cavities by PLGA particles[J].Biomaterials，2009，30（16）：2985-2994.

[17] KUNDU B，KUNDU S C.Silk Sericin/Polyacrylamide in situ Forming Hydrogels for Dermal Reconstruction[J].Biomaterials，2012，33（30）：7456-7467.

[18] XIE H，YANG W，CHEN J，et al.A silk sericin/silicone nerve guidance conduit promotes regeneration of a transected sciatic nerve[J].Adv Healthc Mater， 2015， 4（15）：2195-2205.

[19] LI X，YANG W，XIE H，et al.CNT/sericin conductive nerve guidance conduit promotes functional recovery of transected peripheral nerve injury in a rat model[J].ACS Appl Mater Interfaces，2020，12（33）：36860-36872.

[20] ZHANG L，YANG W，XIE H，et al.Sericin nerve guidance conduit delivering therapeutically repurposed clobetasol for functional and structural regeneration of transected peripheral nerves[J].ACS Biomater Sci Eng，2019，5（3）：1426-1439.

[21] MC NAMARA K，ALZUBAIDI H，JACKSON J K.Cardiovascular disease as a leading cause of death：how are pharmacists getting involved？[J].Integr Pharm Res Pract，2019，8：1-11.

[22] MORI S，TRETTER J T，SPICER D E，et al.What is the real cardiac anatomy？ [J].Clin Anat，2019，32（3）：288-309.

[23] LIEHN E A，POSTEA O，CURAJ A，et al.Repair after myocardial infarction，between fantasy and reality：the role of chemokines[J].J Am Coll Cardiol， 2011， 58（23）：2357-2362.

[24] VUNJAK-NOVAKOVIC G，LUI K O，TANDON N，et al.Bioengineering heart muscle：a paradigm for regenerative medicine[J].Annu Rev Biomed Eng，2011，13：245-267.

[25] OGLE B M，BURSAC N，DOMIAN I，et al.Distilling complexity to advance cardiac tissue engineering[J].Sci Transl Med，2016，8（342）：342ps13.

[26] PEREA-GIL I，PRAT-VIDAL C，BAYES-GENIS A.In vivo experience with natural scaffolds for myocardial infarction：the times they are a-changin’ [J].Stem Cell Res Ther，2015，6：248.

[27] SONG Y，ZHANG C，ZHANG J，et al.An injectable silk sericin hydrogel promotes cardiac functional recovery after ischemic myocardial infarction[J].Acta Biomater，2016，41：210-223.

[28] YILDIRIMER L，THANH N T，SEIFALIAN A M.Skin regeneration scaffolds：a multimodalbottom-up approach[J].Trends Biotechnol，2012，30（12）：638-648.

[29] DONG Y，HASSAN W U，KENNEDY R，et al.Performance of an in situ formed bioactive hydrogel dressing from a PEG-based hyperbranched multifunctional copolymer[J].Acta Biomater，2014，10（5）：2076-2085.

[30] GU Z，XIE H，HUANG C，et al.Preparation of chitosan/silk fibroin blending membrane fixed with alginate dialdehyde for wound dressing[J].Int J Biol Macromol，2013，58：121-126.

[31] DASH B C，MANDAL B B，KUNDU S C.Silk gland sericin protein membranes：fabrication and characterization for potential biotechnological applications[J].J Biotechnol，2009，144（4）：321-329.

[32] FRAGONAS E，VALENTE M，POZZI-MUCELLI M，et al.Articular cartilage repair in rabbits by using suspensions of allogenic chondrocytes in alginate[J].Biomaterials，2000，21：795-801.

[33] SKARDAL A，ZHANG J，MCCOARD L，et al.Photocrosslinkable hyaluronan-gelatin hydrogels for two-step bioprinting[J].Tissue Eng Part A，2010，16 （8）：2675-2685.

[34] LUTOLF M P，RAEBER G P，ZISCH A H，et al.Cell-responsive synthetic hydrogels[J].Adv Mater，2003，15：888-892.

[35] YANG J，ZHANG Y S，YUE K，et al.Cell-laden hydrogels for osteochondral and cartilage tissue engineering[J].Acta Biomater，2017，57：1-25.

[36] HUANG L，TAO K，LIU J，et al.Design and fabrication of multifunctional sericin nanoparticles for tumor targeting and pH-responsive subcellular delivery of cancer chemotherapy drugs[J].ACS Appl Mater Interfaces，2016，8 （10）：6577-6585.

[37] CRIVELLI B，PERTEGHELLA S，BARI E，et al.Silk nanoparticles：from inert supports to bioactive natural carriers for drug delivery[J].Soft Matter，2018，14（4）：546-557.

[38] WANG J，YANG S，LI C，et al.Nucleation and assembly of silica into protein-based nanocomposites as effective anticancer drug carriers using self-assembled silk protein nanostructures as biotemplates[J].ACS Appl Mater Interfaces，2017，9 （27）：22259-22267.

[39] HU D，XU Z，HU Z，et al.pH-triggered charge-reversal silk sericin-based nanoparticles for enhanced cellular uptake and doxorubicin delivery[J].ACS Sustainable Chem Eng，2017，5 （2）：1638-1647.

[40] LAMBONI L，GAUTHIER M，YANG G，et al.Silk sericin：A versatile material for tissue engineering and drug delivery[J].Biotechnol Adv，2015，33（8）：1855-1867.

[41] YANG Y，CAI Y，SUN N，et al.Biomimetic synthesis of sericin and silica hybrid colloidosomes for stimuli-responsive anti-cancer drug delivery systems[J].Colloids Surf B Biointerfaces，2017，151：102-111.

[42] SUKTHAM K，KOOBKOKKRUAD T，WUTIKHUN T，et al.Efficiency of resveratrol-loaded sericin nanoparticles：Promising bionanocarriers for drug delivery[J].Int J Pharm，2018，537 （1-2）：48-56.

[43] SHUAI Y，YANG S，LI C，et al.In situ protein-templated porous protein-hydroxylapatite nanocomposite microspheres for pH-dependent sustained anticancer drug release[J].J Mater Chem B，2017，5 （21）：3945-3954.

[44] MANDAL B B，KUNDU S C.Self-assembled silk sericin/poloxamer nanoparticles as nanocarriers of hydrophobic and hydrophilic drugs for targeted delivery[J].Nanotechnology，2009，20 （35）：355101.

[45] OTSUKI R，YAMAMOTO M，MATSUMOTO E，et al.Bioengineered silkworms with butterfly cytotoxin-modified silk glands produce sericin cocoons with a utility for a new biomaterial[J].Proc Natl Acad Sci USA，2017，114（26）：6740-6745.

[46] DAS S K，DEY T，KUNDU S C.Fabrication of sericin nanoparticles for controlled gene delivery[J].RSC Adv，2014，4（5）：2137-2142.