参考文献

1.Humphries AL Jr，Russerll R，Gregory J，et al. Succesful reimplantation of twenty four hour stored kidney to nephrectomized dog[J]. Ann N Y Acad Sci，1964，120：496-505.

2.Humphries AL Jr，Russerll R，Gregory J，et al. Hypothermic perfusion of the canine kidney for 48 hours followed by reimplantion[J]. Am Surg，1964，30：748-752.

3.Belzer F，Ashby B，Dunphy J.24 hours and 72 hours preservation of canine kidneys[J]. Lancet，1967，2：536.

4.Starzl TE，Groth CG，Brettschneider L，et al. Extended survival in 3 cases of orthotopic homotransplantation of the human liver[J]. Surgery，1968，63（4）：549-563.

5.Beyersdorf F，Mitrev Z，Eckel L，et al. Controlled limb reperfusion as a new surgical technique to reduce postischemic syndrome[J]. The Journal of thoracic and cardiovascular surgery 106，1993：378-380.

6.Schön MR，Kollmar O，Wolf S，et al. Liver transplantation after organ preservation with normothermic extracorporeal perfusion[J]. Ann Surg，2001，233（1）：114-123.

7.Guarrera JV，Henry SD，Samstein B，et al. Hypothermic machine preservation in human liver transplantation：the first clinical series[J]. Am J Transplant，2010，10（2）：372-381.

8.Moers C，Smits JM，Maathuis MH，et al. Machine perfusion or cold storage in deceased-donor kidney transplantation[J]. N Engl J Med，2009，360：7-19.

9.op Den Dries S，Karimian N，Suttonet ME，et al. Ex vivo normothermic machine perfusion and viability testing of discarded human donor livers[J]. Am J Transplant，2013，13（5）：1327-1335.

10.University of Oxford. Device keeps human liver alive outside body[M]. ScienceDaily，2013.www.sciencedaily.com/releases/2013/04/130407150104.htm.

11.Michel SG，La Muraglia GM，Madariaga ML，et al. Preservation of donor hearts using hypothermic oxygenated perfusion[J]. Ann Transplant，2014，19：409-416.

12.van Golen RF，van Gulik TM，Heger M. Mechanistic overview of reactive species-induced degradation of the endothelial glycocalyx during hepatic ischemia/reperfusion injury[J]. Free Radic Biol Med，2012，52：1382.

13.Zhai Y，Petrowsky H，Hong JC，et al. Ischaemia-reperfusion injury in liver transplantation-from bench to bedside[J]. Nat Rev Gastroenterol Hepatol，2013，10：79.

14.Land WG. Emerging role of innate immunity in organ transplantation part II：potential of damage-associated molecular patterns to generate immunostimulatory dendritic cells[J]. Transplant Rev（Orlando），2012，26：73.

15.Belzer FO，Ashby BS，Dunphy JE.24-hour 72-hour preservation of canine kidneys[J]. Lancet，1967，2：536.

16.Schlegel A，Rougemont O，Graf R，et al. Protective mechanisms of end-ischemic cold machine perfusion in DCD liver grafts[J]. J Hepatol，2013，58（2）：278.

17.Tang D，Kang R，Zeh HJ，et al. High-mobility group box 1，oxidative stress，and disease[J]. Antioxid Redox Signal，2011，14（7）：1315.

18.Schlegel A，Kron P，Graf R，et al. Warm vs. cold perfusion technique to rescue rodent liver grafts[J]. J Hepatol，2014.

19.Land WG. Emerging role of innate immunity in organ transplantation：part I：evolution of innate immunity and oxidative allograft injury[J]. Transplant Rev（Orlando），2012，26：60.

20.Loor G，Kondapalli J，Iwase H，et al. Mitochondrial oxidant stress triggers cell death in simulated ischemiareperfusion[J]. Biochim Biophys Acta，2011，1813：1382.

21.Levraut J，Iwase H，Shao ZH，et al. Cell death during ischemia：relationship to mitochondrial depolarization and ROS generation[J]. Am J Physiol Heart Circ Physiol，2003，284：549.

22.van Golen RF，van Gulik TM，Heger M. The sterile immune response during hepatic ischemia/reperfusion[J]. Cytokine Growth Factor Rev 2012；23：69.65.Schlegel A，Rougemont O，Graf R，Clavien PA，Dutkowski P. Protective mechanisms of end-ischemic cold machine perfusion in DCD liver grafts[J]. J Hepatol，2013，58：278.

23.Schlegel A，Graf R，Clavien PA，et al. Hypothermic oxygenated perfusion（HOPE）protects from biliary injury in a rodent model of DCD liver transplantation[J]. J Hepatol，2013，59：984.

24.van Golen RF，Reiniers MJ，Olthof PB，et al. Sterile inflammation in hepatic ischemia/reperfusion injury：present concepts and potential therapeutics[J]. J Gastroenterol Hepatol，2013，28：394.

25.Friedman SL，Sheppard D，Duffield JS，et al. Therapy for fibrotic diseases：nearing the starting line[J]. Sci Transl Med，2013，5：167sr1.

26.Lukacs-Kornek V，Schuppan D. Dendritic cells in liver injury and fibrosis：Shortcomings and promises[J]. J Hepatol，2013，59：1124.

27.Hosgood SA，Nicholson HF，Nicholson ML Oxygenated kidney preservation techniques[J]. Transplantation，2012，93（5）：455-459.

28.La Manna G，Conte D，Cappuccilli ML，et al. An in vivoautotransplant model of renal preservation：cold storage versus machine perfusion in the prevention of ischemia/reperfusion injury[J]. Artif Organs，2009，33（7）：565-570.

29.Bessems M，Doorschodt BM，Kolkert JL，et al. Preservation of steatotic livers：a comparison between cold storage and machine perfusion preservation[J]. Liver Transpl，2007，13：497-504.

30.Gracia-Sancho J，Villarreal G Jr，Zhang Y，et al. Flow cessationtriggers en dothelial dysfunction during organ cold storage conditions：strategies for pharmacologic intervention[J]. Transplantation，2010，90（2）：142-149.

31.Chatauret N，Coudroy R，Delpech PO，et al. Mechanistic analysis of nonoxygenated hypothermic machine perfusion’s protection on warm ischemic kidney uncovers greater eNOS phosphorylation andvasodilation[J]. Am J Transplant，2014，14（11）：2500-2514.

32.Minor T，Manekeller S，Sioutis M，et al. Endoplasmic and preservation[J]. Eur Surg Res，2015，54（3-4）：114-126.

33.Jain S，Xu H，Duncan H，et al. Ex-vivo study of flow dynamics and endothelial eell structure during extended hypothermic machine peffusion preservation of livers[J]. Cryobiology，2004，48（3）：322-332.

34.Marrone G，Maeso-Díaz，Garc a-Cardena G，et al. KLF2 execs antifibrotic and vasoprotective effects in cirrhotic rat livers：behind the molecular mechanisms of statins[J]. Gut，2015，64（9）：1434-1443.

35.Doddaballapur A，Michalik KM，Manavski Y，et al. Laminar shear stress inhibits endothelial cell metabolism via KLF2-mediated repression of PFKFB3[J]. Arterioscler Thromb Vase Biol，2015，35（1）：137-145.

36.Fondevila C，Hessheimer AJ，Maathuis MH，et al. Hypothermic oxygenated machine peHusion in porcine donation after circulatory determination of death liver transplant[J]. Transplantation，2012，94（1）：22-29.

37.Shigeta T，Matsuno N，Obara H，et al. Impact of rewarming preservation by continuous machine peffusion：improved posttransplant recovery in pigs[J]. Transplant Proc，2013，45：1684-1689.

38.Saad S，Minor T. Short-term resuscitation of predamaged donor livers by brief machine perfusion：the influence of temperature[J]. Transplant Proc，2008，40：3321-3326.

39.Tolboom H，Pouw RE，Izamis ML，et al. Recovery of warm ischemic rat liver grafts by normothermic extracorporeal perfusion[J]. Transplantation，2009，87：170-177.

40.Vajdova K，Smrekova R，Mislanova C，et al. Coldpreservation-induced sensitivity of rat hepatocyte function to rewarming injury and its prevention by short-term reperfusion[J]. Hepatology，2000，32：289-296.

41.Stegemann J，Minor T. Energy charge restoration，mitochondrial protection and reversal of preservation induced liver injury by hypothermic oxygenation prior to reperfusion[J]. Cryobiology，2009，58（3）：0-336.

42.Brasile L，Buelow R，Stubenitsky BM，et al. Induction of heme oxygenase-1 in kidneys during ex vivo warm perfusion[J]. Transplantation，2003，76：1145-1149.

43.Brockrnann J，Reddy S，Coussios C，et al. Normothermic perfusion：a new paradigm for organ preservation[J]. Ann Surg，2009，250（1）：1-6.

44.Hosgood SA，Barlow AD，Yates PJ，et al. A pilot study assessing the feasibility of a short period of normothermic preservation in an experimental model of non heart beating donor kidneys[J]. J Surg Res，2011，171（1）：283-290.

45.Lindstedt S，Hlebowicz J，Koul B，et al. Comparative outcome of double lung transplantation using conventional donor lungs and nonacceptable donor lungs reconditioned ex vivo[J]. Interact Cardiovasc Thorac Surg，2011，12（2）：162-165.

46.Ravikumar R，Jassem W，Mergental H，et al. Liver transplantation after ex vivo normothermic machine preservation：a Phase 1（first-in-man）clinical trial[J]. Am J Transplant，2016，16（6）：1779-1787.

47.Perera M，Mergental H，Stephenson B，et al. First human liver transplantation using a marginal allograft resuscitated by normothermic machine perfusion[J]. Liver Transpl，2015.

48.Guarrera JV，Henry SD，Samstein B，et al. Hypothermic machine preservation in human liver transplantation：the first clinical series[J]. Am J Transplant；10：372-381.

49.Guarrera JV，Henry SD，Samstein B，et al. Hypothermic machine preservation facilitates successful transplantation of“orphan”extended criteria donor livers[J]. Am J Transplant，2015，15：161-169.

50.Dutkowski P，Schlegel A，de Oliveira M，et al. HOPE for human liver grafts obtained from donors after cardiac death[J]. J Hepatol，2014，60：765-772.

51.Rosenthal JT，Herman JB，Taylor RJ，et al. Comparison of pulsatile machine perfusion with cold storage for cadaver kidney preservation[J]. Transplantation，1984，37：425-426.

52.Halloran P，Aprile M. A randomized prospective trial of cold storage versus pulsatile perfusion for cadaver kidney preservation[J]. Transplantation，1987，43：827-832.

53.Jaffers GJ，Banowsky LH. The absence of a deleterious effect of mechanical kidney preservation in the era of cyclosporine[J]. Transplantation，1989，47：734-736.

54.Siedlecki A，Irish W，Brennan DC. Delayed graft function in the kidney transplant[J]. Am J Transplant，2011，11：2279-2296.

55.Sedigh A，Tufveson G，Backman L，et al. Initial experience with hypothermic machine perfusion of kidneys from deceased donors in the Uppsala region in Sweden[J]. Transplant Proc；45：1168-1171.

56.Deng R，Gu G，Wang D，et al. Machine perfusion versus cold storage of kidneys derived from donation after cardiac death：a meta-analysis[J]. PLoS One 2013；8：e56368.

57.Kwiatkowski A，Wszola M，Perkowska-Ptasinska A，et al. Influence of preservation method on histopathological lesions of kidney allografts[J]. Ann Transplant，2009，14：10-13.

58.Garfield SS，Poret AW，Evans RW. The cost-effectiveness of organ preservation methods in renal transplantation：US projections based on the machine preservation trial[J]. Transplant Proc，2009，41：3531-3536.

59.Moers C，Pirenne J，Paul A，et al. Machine Preservation Trial Study G. Machine perfusion or cold storage in deceased-donor kidney transplantation[J]. N Engl J Med，2012，366：770-771.

60.Lee CY，Jain S，Duncan HM，et al. Survival transplantation of preserved non-heart-beating donor rat livers：preservation by hypothermic machine perfusion[J]. Transplantation，2003，76：1432-1436.

61.Fuller BJ，Pegg DE. The assessment of renal preservation by normothermic bloodless perfusion[J]. Cryobiology，1976，13：177-184.

62.Hosgood SA，Nicholson ML. First in man renal transplantation after ex vivo normothermic perfusion[J]. Transplantation，2011，92：735-738.

63.Nicholson ML，Hosgood SA. Renal transplantation after ex vivo normothermic perfusion：the first clinical study[J]. Am J Transplant，2013，13：1246-1252.

64.Rosenbaum DH，Peltz M，DiMaio JM，et al. Perfusion preservation versus static preservation for cardiac transplantation：effects on myocardial function and metabolism[J]. J Heart Lung Transplant，2008，27：93-99.

65.Peltz M，He TT，Adams GAt，et al. Perfusion preservation maintains myocardial ATP levels and reduces apoptosis in an ex vivo rat heart transplantation model[J]. Surgery，2005，138：795-805.

66.Cobert ML，Merritt ME，West LM，et al. Metabolic characteristics of human hearts preserved for 12 hours by static storage，antegrade perfusion，or retrograde coronary sinus perfusion[J]. J Thorac Cardiovasc Surg，2014，148：2310-2315 e2311.

67.Onorati F，Santarpino G，Cristodoro L，et al. Continuous coronary sinus perfusion reverses ongoing myocardial damage in acute ischemia[J]. Artif Organs，2009，33：788-797.PMID：20063441.

68.Stamp NL，Shah A，Vincent V，et al. Successful Heart Transplant after Ten Hours Out-of-body Time using the TransMedics Organ Care System[J]. Heart Lung Circ，2015，24：611-613.

69.Warnecke G，Moradiellos J，Tudorache I，et al. Normothermic perfusion of donor lungs for preservation and assessment with the Organ Care System Lung before bilateral transplantation：a pilot study of 12 patients[J]. Lancet，2012，380：1851-1858.

70.Perera MT，Clutton-Brock T，Muiesan P. One donor，two types of preservation：first description of a donation after circulatory death donor with normothermic abdominal perfusion and simultaneous cold perfusion of lungs[J]. Liver Transpl，2014，20：1012-1015.

71.Ardehali A，Esmailian F，Deng M，et al. Ex-vivo perfusion of donor hearts for human heart transplantation（PROCEED Ⅱ）：a prospective，open-label，multicentre，randomised non-inferiority trial[J]. Lancet，2015，385：2577-2584.

72.Van Caenegem O，Beauloye C，Bertrand L，et al. Hypothermic continuous machine perfusion enables preservation of energy charge and functional recovery of heart grafts in an ex vivo model of donation following circulatory death[J]. Eur J Cardiothorac Surg，2015，45：1348-1353.

73.Kay MD，Hosgood SA，Harper SJ，et al. Static normothermic preservation of renal allografts using a novel nonphosphate buffered preservation solution[J]. Transpl Int，2007，20：88-92.

74.Thiara AP，Hoel TN，Kristiansen F，et al. Evaluation of oxygenators and centrifugal pumps for long-term pediatric extracorporeal membrane oxygenation[J]. Perfusion，2007，22：323-326.

75.Bagul A，Hosgood SA，Kaushik M，et al. Experimental renal preservation by normothermic resuscitation perfusion with autologous blood[J]. Br J Surg，2008，95：111-118.

76.Hosgood SA，van Heurn E，Nicholson ML. Normothermic machine perfusion of the kidney：better conditioning and repair?[J]. Transpl Int，2015，28：657-664.

77.Monbaliu D，Brassil J. Machine perfusion of the liver：past，present and future[J]. Curr Opin Organ Transplant；15：160-166.

78.Jomaa A，Gurusamy K，Siriwardana PN，et al. Does hypothermic machine perfusion of human donor livers affect risks of sinusoidal endothelial injury and microbial infection?A feasibility study assessing flow parameters，sterility，and sinusoidal endothelial ultrastructure[J]. Transplant Proc；45：1677-1683.

79.Compagnon P，Clement B，Campion JP，et al. Effects of hypothermic machine perfusion on rat liver function depending on the route of perfusion[J]. Transplantation，2001，72：606-614.

80.t Hart NA，der van Plaats A，Leuvenink HG，et al. Determination of an adequate perfusion pressure for continuous dual vessel hypothermic machine perfusion of the rat liver[J]. Transpl Int，2007，20：343-352.

81.Vekemans K，Liu Q，Pirenne J，et al. Artificial circulation of the liver：machine perfusion as a preservation method in liver transplantation[J]. Anat Rec（Hoboken），2008，291：735-740.

82.Hessheimer AJ，Fondevila C，Garcia-Valdecasas JC. Extracorporeal machine liver perfusion：are we warming up?[J]. Curr Opin Organ Transplant；17：143-147.

83.Tullius SG，Garcia-Cardena G. Organ procurement and perfusion before transplantation[J]. N Engl J Med，2009，360：78-80.

84.Olschewski P，Gass P，Ariyakhagorn V，et al. The influence of storage temperature during machine perfusion on preservation quality of marginal donor livers[J]. Cryobiology，2010，60：337-343.

85.van der Plaats A，t Hart NA，Verkerke GJ，et al. Hypothermic machine preservation in liver transplantation revisited：concepts and criteria in the new millennium[J]. Ann Biomed Eng，2004，32：623-631.

86.van der Plaats A，Maathuis MH，NA TH，et al. The Groningen hypothermic liver perfusion pump：functional evaluation of a new machine perfusion system[J]. Ann Biomed Eng，2006，34：1924-1934.

87.t Hart NA，van der Plaats A，Moers C，et al. Development of the isolated dual perfused rat liver model as an improved reperfusion model for transplantation research[J]. Int J Artif Organs，2006，29：219-227.

88.Nasralla D，Coussios C C，Mergental H，et al. A randomized trial of normothermic preservation in liver transplantation[J]. Nature，2008，557：50-56.